Joseph "Uncle Joe" Cannon (1836–1926), att. Law 1858, 40th speaker of the U.S. House of Representatives, 1903-11; cumulatively served 48 years in Congress; cover subject of the first issue of Time magazine in 1923. The Cannon House Office Building, named for him, is the oldest congressional office building in Washington, D.C.
Judson Harmon (1846-1927), Law 1870, U.S. attorney general, 1895-97; Ohio governor, 1909-13
James Beauchamp "Champ" Clark (1850–1921), Law 1875, 41st Speaker of the U.S. House of Representatives, 1911-19
Lawrence Maxwell Jr. (1853-1927), Law 1875, U.S. solicitor general, 1893-95
Nicholas Longworth IV (1869–1931), Law 1894, 43rd Speaker of the U.S. House of Representatives, 1925-31
Charles Sawyer (1887-1979), Law '11, U.S. secretary of Commerce, 1948-53; ambassador to Belgium and Luxembourg, 1944-45
Theodore "Ted" Berry (1905-2000), Law '31, first African-American mayor of Cincinnati, pivotal attorney in the Civil Rights Movement for the NAACP
Helen Elsie Austin (1908-2004), Law '30, U.S. Foreign Service officer, 1960-70; first black woman to graduate from UC College of Law and one of he first African Americans admitted to the practice of law in the U.S.
John "Jack" Gilligan, Law '47, governor of Ohio, 1970-75; administrator of U.S. Agency for International Development, 1977-79; director of the U.S. Institute for Public Policy, 97-86
Robert Taft II, JD '76, HonDoc ’00, 67th governor of Ohio, 1999-2007. (Yes, it’s the same family as William Howard.)
John Altenburg, Law '73, U.S. Army major general, military lawyer and appointing authority for military commissions covering detainees at Guantanamo, 2003-06